Tamoxifen hot flashes

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    Tamoxifen hot flashes


    Hot flashes and night sweats are common in cancer survivors, particularly women, but they can also occur in men. Treatment options are broad-based, including hormonal agents, nonhormonal pharmacotherapies, and diverse integrative medicine modalities.[1] Hot flashes occur in approximately two-thirds of postmenopausal women with a breast cancer history and are associated with night sweats in 44%.[2,3] For most breast cancer and prostate cancer patients, hot flash intensity is moderate to severe. Sweating can be part of the hot flash complex that characterizes the vasomotor instability of menopause. Physiologically, sweating mediates core body temperature by producing transdermal evaporative heat loss.[4,5] Hot flashes accompanied by sweating that occur during the sleeping hours are often called Approximately 20% of women without breast cancer seek medical treatment for postmenopausal symptoms, including symptoms related to vasomotor instability.[7] Vasomotor symptoms resolve spontaneously in most patients in this population, with only 20% of affected women reporting significant hot flashes 4 years after the last menses.[7] There are no comparable data for women with metastatic breast cancer. Three-quarters of men with locally advanced or metastatic prostate cancer treated with medical or surgical orchiectomy experience hot flashes.[8] In this summary, unless otherwise stated, evidence and practice issues as they relate to adults are discussed. The evidence and application to practice related to children may differ significantly from information related to adults. When specific information about the care of children is available, it is summarized under its own heading. Causes of menopausal hot flashes include the occurrence of natural menopause, surgical menopause, or chemical menopause; in the cancer patient, chemical menopause may be caused by cytotoxic chemotherapy, radiation therapy, or androgen treatment. Tamoxifen will continue to be an important drug for the treatment of hormone-dependent breast cancer despite results suggesting that aromatase inhibitors will play an increasing role in the treatment of breast cancer for postmenopausal women . With more drugs available to treat patients with breast cancer, it is clear that patients would benefit from information that would allow their health care providers to individualize therapy. However, designing individualized therapies is complicated because for many drugs, including tamoxifen, the efficacies and toxicities differ among patients. The reasons for many of the interindividual differences are unknown. Despite its proven benefit, tamoxifen is known to have adverse side effects, including increased risks of endometrial cancer and vascular-related thrombotic events (i.e., stroke, venous thrombosis, and pulmonary emboli), as well as non–life-threatening side effects that can reduce quality of life and can affect patient compliance. Hot flashes, the most common side effect of tamoxifen, occur in up to 80% of women receiving tamoxifen . Although hormone replacement therapy is the most effective treatment for reducing hot flashes, its use in women with a history of breast cancer is generally not recommended because of a concern that pharmacologic doses of hormones could promote growth of subclinical breast cancer metastases.

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    Tamoxifen may cause cancer of the uterus womb, strokes, and blood clots in the lungs. These conditions may be serious or fatal. Tell your doctor if you have ever had a blood clot in the lungs or legs, a stroke, or a heart attack. Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator SERM. Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. Natural Remedies For Tamoxifen Withdrawal Side Effects. If you are in the process of weaning yourself off of tamoxifen and there are many reasons why you might want to do so and need help with the resulting withdrawal side effects, this article shares

    If you’ve had one, there’s no mistaking it: the sudden, intense, hot feeling on your face and upper body, perhaps preceded or accompanied by a rapid heartbeat and sweating, nausea, dizziness, anxiety, headache, weakness, or a feeling of suffocation. Some women experience an “aura,” an uneasy feeling just before the hot flash that lets them know what’s coming. Every woman’s experience is a little bit different. The flash is followed by a flush, leaving you reddened and perspiring. However, the faster you transition from regular periods to no periods, the more significant your hot flashes may be. Some premenopausal women who have their ovaries removed can experience severe hot flashes due to surgical menopause. Chemotherapy-induced medical menopause can cause hot flashes, as can hormonal therapies such as tamoxifen. Overall, the severity of hot flashes can vary from mild to moderate to severe. If you haven’t been warned about hot flashes, a sudden severe episode can be frightening: it can have some of the same symptoms as a panic attack or a heart attack. Compared to chemotherapy, tamoxifen has fewer side effects. Menopausal symptoms (such as hot flashes) are common in women who take tamoxifen [75]. Although menopausal symptoms may become less frequent and less intense over time, they can still be hard to manage. If you have symptoms, talk with your health care provider about ways to treat them. The most serious health risks of tamoxifen, such as endometrial cancer (cancer of the lining of the uterus) and blood clots in the lungs, are rare [75]. Figure 5.10 lists some possible side effects and health risks of tamoxifen in women. Although both aromatase inhibitors and tamoxifen can cause menopausal symptoms such as hot flashes, many of their side effects differ. Learn about how the side effects of these hormone therapies compare.

    Tamoxifen hot flashes

    Side Effects of Tamoxifen Susan G. Komen®, Tamoxifen C26H29NO - PubChem

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  3. Chemotherapy-induced medical menopause can cause hot flashes, as can hormonal therapies such as tamoxifen. Overall, the severity of hot flashes can vary from mild to moderate to severe. If you haven’t been warned about hot flashes, a sudden severe episode can be frightening it can have some of the same symptoms as a panic attack or a heart.

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    Causes of “male menopause” include orchiectomy, gonadotropin-releasing hormone use, or estrogen use. Drug-associated causes of hot flashes and night sweats in men and women include tamoxifen, aromatase inhibitors, opioids, tricyclic antidepressants, and steroids. The drug Tamoxifen is used around the world to help treat breast cancer. But it’s also causing women a lot of grief! Like many cancer-treatment drugs, Tamoxifen comes with several possible side effects. The most common ones are menopausal symptoms-specifically, hot flashes. In the context of the menopause, hormone replacement therapy HRT is the use of estrogen in women without a uterus and estrogen plus progestin in women who have an intact uterus. HRT may be reasonable for the treatment of menopausal symptoms, such as hot flashes. It is the most effective treatment option, especially when delivered as a skin patch.

     
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