Duloxetine and venlafaxine are 2 selective SNRIs considered appropriate for neuropathic pain patients, although new data suggest duloxetine may be a superior option to venlafaxine. A new study conducted by researchers based out of the VA Tennessee Valley Healthcare System in Murfreesboro, Tennessee, completed a head-to-head analysis between the 2 drugs, examining the percentage of patients able to achieve a therapeutic dose, time taken to reach therapeutic dose, and any adverse effects associated with the treatments. They found significantly more patients were able to achieve a therapeutic dose taking duloxetine. Titrating to a therapeutic dose was also much faster compared to venlafaxine. Duloxetine also appeared to be an effective alternative for patients who had been nonresponders to previous venlafaxine therapy. “When looking at efficacy in neuropathic pain, these medications are thought to be comparable,” because up to this point, there simply has been a lack of research into which medication could be more preferable, lead investigator Kelsie Flynn, Pharm D, told . Given that health care systems base such formulary decisions on cost, generic venlafaxine has been considered the more cost-effective treatment. Hi Trish: I use Cymbalta for abdomen, neck and hand pain and Fibromyalgia. There are some unpleasant side effects such as nausea and being light headed upon standing being the worst for me. I couldn't take the side effects from either of those two. Without it my pains levels are considerably higher. All in all, it's well worth the unpleasant side effects for me. My doctor had prescribed me Cymbalta for nerve pain, as I suffer with Degenerative Disk Disease and Sciatica. Whether or not you decide to try Cymbalta is strictly between you and your doctor. I found it helped a bit, but haven't taken it since the end of 2008, as I got pregnant. I found that it made me a bit tired in the beginning, but my body soon adjusted. If I recall, it took about 3 weeks before it was really noticeable as effective. In addition to anything I have mentioned, please keep in mind, that while I or others may have extensive knowledge in many areas, you should always seek professional medical advice from your own physician, as it pertains to medical conditions or concerns. Good luck, and if you have any other questions that I can help you with, please feel free to message me directly. Sincerely, Sandi (Dragon1973) Med Help Down syndrome Community Leader & Ds Group Forum Founder/Moderator Hi Trish, I think that I have discussed this before with you. As I said I have taken Cymbalta before and did not not any difference in my sciatica. Azithromycin facts Retin a where can i buy it Everything you need to know about taking duloxetine hcl or the branded version Cymbalta, an antidepressant medicine used to treat anxiety, depression and. Duloxetine is thought relieve nerve pain by enhancing the nerve signals within the central nervous system that naturally inhibit nerve pain duloxetine may start to help in a few days for some people, while others don't see much difference for several weeks. Does duloxetine work to treat pain generated by nerves when they have been damaged in disease, or the pain caused by fibromyalgia?Pain can arise spontaneously when there is damage to nerves that carry pain information to the brain neuropathic pain. When this damage is to nerves outside the. Duloxetine is a medication in the class of anti-depressant drugs, used to treat major depression and provide relief from nerve pain or peripheral neuropathy in diabetics. It belongs to a class of medicines called the selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Originally produced by Lilly researchers, Duloxetine hydrochloride was patented in 1981 and was approved for use by the Food and Drug Administration (FDA) in 2004. The drug is sold under the drug name Cymbalta and is officially prescribed for the following purposes: Duloxetine is also sold under the brand names Duloxetine HCI, Duloxetine Hydrochloride and Yentreve. A report published in the journal, Diabetes Care, January 2007, indicates that duloxetine might raise the blood glucose levels, both over a short as well as long time periods. Cholesterol levels were also found to be slightly affected by duloxetine, while weight loss was experienced by some patients in short-term use. Duloxetine primarily works by restoring the balance of two kinds of natural substances, including neurotransmitters known as serotonin and norepinephrine in the brain. The following information is NOT intended to endorse drugs or recommend therapy. I am still taking 30 mg.""I don't usually leave reviews for anything and I researched this drug and saw so many negative comments about it so I thought I would leave a positive one. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."Put on Cymbalta 30 mg with intentions of going up to 60 mg. People seem to try this for 1 - 3 days and give up, how is this giving the drug a good chance at working? It was for anxiety, panic attacks, chronic pain from back surgery, stenosis of spine and cervical fusion. I have had chronic musculoskeletal lower back pain for just over a year now without any opiates working long term, so my doctor prescribed Cymbalta 30mgs to start with, yes I did have side effects... Only complaint is that I have gained 10lbs and I am hungry all the time. nausea, insomnia, lack of concentration, fainting, headaches etc but when you are desperate for pain relief you try anything and I stuck it out for the 2 weeks and all the side effects have gone, I now gone up to 60mgs and I feel this is kicking in quite nicely, I don't need my pain patches anymore etc""I was prescribed this for depression and chronic pain. The first time I took it was at night as instructed by physician. I was given 30mg I honestly thought it was going to die. Duloxetine for nerve pain Duloxetine for treating painful neuropathy, chronic, Duloxetine Cymbalta for depression, anxiety or nerve What is premarin and side effects for male partner Duloxetine for chronic musculoskeletal pain. Duloxetine may have potential advantages for patients with chronic musculoskeletal pain and comorbid depression, and/or anxiety, simply because in this situation clinicians may be able to treat more Duloxetine in the management of chronic musculoskeletal pain. Duloxetine for treating painful neuropathy, chronic pain. Duloxetine More Effective at Treating Neuropathic. My doctor had prescribed me Cymbalta for nerve pain, as I suffer with Degenerative Disk Disease and Sciatica. I found it helped a bit, but haven't taken it since the. Reviews and ratings for duloxetine when used in the treatment of back pain. 41 reviews submitted. Duloxetine is a nerve pain medication and antidepressant. It can help treat depression, anxiety, fibromyalgia, diabetic peripheral neuropathy, and other conditions related to chronic muscle or bone pain. Common brand names include Cymbalta and Irenka.